Endometriosis and depression comorbidity: links with gastritis, and peptic ulcer disease

A growing body of evidence suggests a co-occurring relationship between endometriosis and depression. However, there is no clear understanding of the relationship nor the potential mechanisms of the association. A new study, "Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality", comprehensively assessed the relationship between endometriosis and depression using genetic study approach. Findings confirmed the comorbidity of endometriosis and depression and suggest the likely role of gastric mucosa disorders (gastritis, duodenitis, peptic ulcer, and gastroesophageal reflux disease) in the causal pathways of the two disorders.

                                                                Photo by Naomi August on Unsplash 

The study which was published in Human Genetics, identified genetic factors shared by both endometriosis and depression including SNPs, loci and genes. These genetic factors may serve as potential targets for drug development in the future treatment of endometriosis or depression. Also, potential biological pathways underlying the two disorders were identified in the study thereby improving our knowledge of the biological mechanisms underlying endometriosis and depression.  

 

Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality

Rural-urban differences on the rates and factors associated with early initiation of breastfeeding in Nigeria: further analysis of the Nigeria demographic and health survey, 2013

Early initiation of breastfeeding in Nigeria

Rural-urban differences on the rates and factors associated with early initiation of breastfeeding in Nigeria: further analysis of the Nigeria demographic and health survey, 2013

 

International Breastfeeding Journal.

Emmanuel Olorunleke Adewuyi
Yun Zhao
Vishnu Khanal
Asa Auta
and Lydia Babatunde Bulndi


Abstract
Background: This study investigates and compares the rates and factors associated with early initiation of breastfeeding (EIBF) within one hour of birth in rural and urban Nigeria.
Methods: Data from the 2013 Nigeria Demographic and Health Survey (NDHS) were analyzed. The rates of EIBF were reported using frequency tabulation. Associated factors were examined using Chi-Square test and further assessed on multivariable logistic regression analysis.
Results: The rates of EIBF were 30.8% (95% confidence interval [CI] 29.0, 32.6) and 41.9% (95% CI 39.6, 44.3) in rural and urban residences, respectively (p< 0.001). The North-Central region had the highest EIBF rates both in rural (43.5%) and urban (63.5%) residences. Greater odds of EIBF in rural residence were significantly associated with higher birth order (Adjusted Odds Ratio [AOR] 1.29, 95% CI 1.10, 1.60), large birth size (AOR 1.33, 95% CI 1.10, 1.60), and health facility delivery (AOR 1.46, 95% CI 1.23, 1.72). Rural mothers in the rich wealth index, not working and whose husbands obtained at least a secondary school education had significantly higher odds of early initiation of breastfeeding. Regardless of residence, greater odds of EIBF were significantly associated with non-cesarean delivery (Rural AOR 3.50, 95% CI 1.84, 6.62; Urban AOR 2.48, 95% CI 1.60, 3.80) and living in North-Central (Rural AOR 1.84, 95% CI 1.34, 2.52; Urban AOR 4.40, 95% CI 3.15, 6.15) region. Also, higher odds of EIBF were significantly associated with living in
North-East (Rural AOR 1.48, 95% CI 1.05, 2.08; Urban AOR 3.50, 95% CI 2.55, 4.83), South-South (Rural AOR 1.51, 95% CI 1.11, 2.10; Urban AOR 2.84, 95% CI 2.03, 3.97) and North-West (Urban residence only AOR 2.08, 95% CI 1.54, 2.80) regions.
Conclusions: Rural-urban differences in the rates and factors associated with EIBF exist in Nigeria with rural residence having significantly lower rates. Intervention efforts which address the risk factors identified in this study may contribute to improved EIBF rates. Efforts need to prioritize rural mothers generally, (particularly, those in rural North-West region) as well as mothers in urban South-West region of Nigeria.

Keywords:Breastfeeding initiation, Determinants, Infants feeding, Mothers, Rural-urban Nigeria

Access this article on the website of International Breastfeeding Journal.