Endometriosis and depression comorbidity: links with gastritis, and peptic ulcer disease

A growing body of evidence suggests a co-occurring relationship between endometriosis and depression. However, there is no clear understanding of the relationship nor the potential mechanisms of the association. A new study, "Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality", comprehensively assessed the relationship between endometriosis and depression using genetic study approach. Findings confirmed the comorbidity of endometriosis and depression and suggest the likely role of gastric mucosa disorders (gastritis, duodenitis, peptic ulcer, and gastroesophageal reflux disease) in the causal pathways of the two disorders.

                                                                Photo by Naomi August on Unsplash 

The study which was published in Human Genetics, identified genetic factors shared by both endometriosis and depression including SNPs, loci and genes. These genetic factors may serve as potential targets for drug development in the future treatment of endometriosis or depression. Also, potential biological pathways underlying the two disorders were identified in the study thereby improving our knowledge of the biological mechanisms underlying endometriosis and depression.  

 

Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality